Macrophage migration inhibitory factor promoter polymorphisms are associated with disease activity in rheumatoid arthritis patients from Southern Mexico
Identifieur interne : 000660 ( Main/Exploration ); précédent : 000659; suivant : 000661Macrophage migration inhibitory factor promoter polymorphisms are associated with disease activity in rheumatoid arthritis patients from Southern Mexico
Auteurs : Guillermo Santoscoy-Ascencio ; Christian Johana Ba Os-Hernández ; José Eduardo Navarro-Zarza ; Jorge Hernández-Bello ; Richard Bucala ; Andres L Pez-Quintero ; Emmanuel Valdés-Alvarado ; Isela Parra-Rojas ; Berenice Illades-Aguiar ; José Francisco Mu Oz-ValleSource :
- Molecular Genetics & Genomic Medicine [ 2324-9269 ] ; 2019.
Abstract
Macrophage migration inhibitory factor (MIF) is a cytokine capable of stimulating inflammatory cytokine and matrix metalloproteinase production from macrophages and synovial fibroblasts, which leads to persistent inflammation and bone degradation, two of the major pathological processes in rheumatoid arthritis (RA). The aim of this study was to evaluate the association of
A case–control study was conducted in 200 RA patients and 200 control subjects (CS) from Southern Mexico. Genotyping was performed by conventional PCR and PCR‐RFLP methods.
The 7,7 (−794CATT5‐8) and −173CC (−173G > C) genotypes were associated with higher disease activity in RA patients. MIF serum levels were increased, and
These results suggest an important role of
Url:
DOI: 10.1002/mgg3.1037
PubMed: 31701681
PubMed Central: 6978234
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Macrophage migration inhibitory factor promoter polymorphisms are associated with disease activity in rheumatoid arthritis patients from Southern Mexico</title><author><name sortKey="Santoscoy Scencio, Guillermo" sort="Santoscoy Scencio, Guillermo" uniqKey="Santoscoy Scencio G" first="Guillermo" last="Santoscoy-Ascencio">Guillermo Santoscoy-Ascencio</name><affiliation><nlm:aff id="mgg31037-aff-0001"></nlm:aff></affiliation><affiliation><nlm:aff id="mgg31037-aff-0002"></nlm:aff></affiliation></author><author><name sortKey="Ba Os Ernandez, Christian Johana" sort="Ba Os Ernandez, Christian Johana" uniqKey="Ba Os Ernandez C" first="Christian Johana" last="Ba Os-Hernández">Christian Johana Ba Os-Hernández</name><affiliation><nlm:aff id="mgg31037-aff-0001"></nlm:aff></affiliation><affiliation><nlm:aff id="mgg31037-aff-0003"></nlm:aff></affiliation></author><author><name sortKey="Navarro Arza, Jose Eduardo" sort="Navarro Arza, Jose Eduardo" uniqKey="Navarro Arza J" first="José Eduardo" last="Navarro-Zarza">José Eduardo Navarro-Zarza</name><affiliation><nlm:aff id="mgg31037-aff-0004"></nlm:aff></affiliation></author><author><name sortKey="Hernandez Ello, Jorge" sort="Hernandez Ello, Jorge" uniqKey="Hernandez Ello J" first="Jorge" last="Hernández-Bello">Jorge Hernández-Bello</name><affiliation><nlm:aff id="mgg31037-aff-0001"></nlm:aff></affiliation><affiliation><nlm:aff id="mgg31037-aff-0005"></nlm:aff></affiliation></author><author><name sortKey="Bucala, Richard" sort="Bucala, Richard" uniqKey="Bucala R" first="Richard" last="Bucala">Richard Bucala</name><affiliation><nlm:aff id="mgg31037-aff-0006"></nlm:aff></affiliation></author><author><name sortKey="L Pez Uintero, Andres" sort="L Pez Uintero, Andres" uniqKey="L Pez Uintero A" first="Andres" last="L Pez-Quintero">Andres L Pez-Quintero</name><affiliation><nlm:aff id="mgg31037-aff-0001"></nlm:aff></affiliation><affiliation><nlm:aff id="mgg31037-aff-0005"></nlm:aff></affiliation></author><author><name sortKey="Valdes Lvarado, Emmanuel" sort="Valdes Lvarado, Emmanuel" uniqKey="Valdes Lvarado E" first="Emmanuel" last="Valdés-Alvarado">Emmanuel Valdés-Alvarado</name><affiliation><nlm:aff id="mgg31037-aff-0001"></nlm:aff></affiliation></author><author><name sortKey="Parra Ojas, Isela" sort="Parra Ojas, Isela" uniqKey="Parra Ojas I" first="Isela" last="Parra-Rojas">Isela Parra-Rojas</name><affiliation><nlm:aff id="mgg31037-aff-0003"></nlm:aff></affiliation></author><author><name sortKey="Illades Guiar, Berenice" sort="Illades Guiar, Berenice" uniqKey="Illades Guiar B" first="Berenice" last="Illades-Aguiar">Berenice Illades-Aguiar</name><affiliation><nlm:aff id="mgg31037-aff-0003"></nlm:aff></affiliation></author><author><name sortKey="Mu Oz Alle, Jose Francisco" sort="Mu Oz Alle, Jose Francisco" uniqKey="Mu Oz Alle J" first="José Francisco" last="Mu Oz-Valle">José Francisco Mu Oz-Valle</name><affiliation><nlm:aff 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Os-Hernández</name><affiliation><nlm:aff id="mgg31037-aff-0001"></nlm:aff></affiliation><affiliation><nlm:aff id="mgg31037-aff-0003"></nlm:aff></affiliation></author><author><name sortKey="Navarro Arza, Jose Eduardo" sort="Navarro Arza, Jose Eduardo" uniqKey="Navarro Arza J" first="José Eduardo" last="Navarro-Zarza">José Eduardo Navarro-Zarza</name><affiliation><nlm:aff id="mgg31037-aff-0004"></nlm:aff></affiliation></author><author><name sortKey="Hernandez Ello, Jorge" sort="Hernandez Ello, Jorge" uniqKey="Hernandez Ello J" first="Jorge" last="Hernández-Bello">Jorge Hernández-Bello</name><affiliation><nlm:aff id="mgg31037-aff-0001"></nlm:aff></affiliation><affiliation><nlm:aff id="mgg31037-aff-0005"></nlm:aff></affiliation></author><author><name sortKey="Bucala, Richard" sort="Bucala, Richard" uniqKey="Bucala R" first="Richard" last="Bucala">Richard Bucala</name><affiliation><nlm:aff id="mgg31037-aff-0006"></nlm:aff></affiliation></author><author><name sortKey="L Pez Uintero, Andres" sort="L Pez Uintero, Andres" uniqKey="L Pez Uintero A" first="Andres" last="L Pez-Quintero">Andres L Pez-Quintero</name><affiliation><nlm:aff id="mgg31037-aff-0001"></nlm:aff></affiliation><affiliation><nlm:aff id="mgg31037-aff-0005"></nlm:aff></affiliation></author><author><name sortKey="Valdes Lvarado, Emmanuel" sort="Valdes Lvarado, Emmanuel" uniqKey="Valdes Lvarado E" first="Emmanuel" last="Valdés-Alvarado">Emmanuel Valdés-Alvarado</name><affiliation><nlm:aff id="mgg31037-aff-0001"></nlm:aff></affiliation></author><author><name sortKey="Parra Ojas, Isela" sort="Parra Ojas, Isela" uniqKey="Parra Ojas I" first="Isela" last="Parra-Rojas">Isela Parra-Rojas</name><affiliation><nlm:aff id="mgg31037-aff-0003"></nlm:aff></affiliation></author><author><name sortKey="Illades Guiar, Berenice" sort="Illades Guiar, Berenice" uniqKey="Illades Guiar B" first="Berenice" last="Illades-Aguiar">Berenice Illades-Aguiar</name><affiliation><nlm:aff id="mgg31037-aff-0003"></nlm:aff></affiliation></author><author><name sortKey="Mu Oz Alle, Jose Francisco" sort="Mu Oz Alle, Jose Francisco" uniqKey="Mu Oz Alle J" first="José Francisco" last="Mu Oz-Valle">José Francisco Mu Oz-Valle</name><affiliation><nlm:aff id="mgg31037-aff-0001"></nlm:aff></affiliation><affiliation><nlm:aff id="mgg31037-aff-0005"></nlm:aff></affiliation></author></analytic><series><title level="j">Molecular Genetics & Genomic Medicine</title><idno type="eISSN">2324-9269</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Abstract</title><sec id="mgg31037-sec-0001"><title>Background</title><p>Macrophage migration inhibitory factor (MIF) is a cytokine capable of stimulating inflammatory cytokine and matrix metalloproteinase production from macrophages and synovial fibroblasts, which leads to persistent inflammation and bone degradation, two of the major pathological processes in rheumatoid arthritis (RA). The aim of this study was to evaluate the association of <italic>MIF</italic> promoter polymorphisms (−794CATT<sub>5‐8</sub><italic>rs5844572</italic> and −173G > C, <italic>rs755622</italic>), circulating MIF levels, and mRNA expression with RA susceptibility and disease activity.</p></sec><sec id="mgg31037-sec-0002"><title>Methods</title><p>A case–control study was conducted in 200 RA patients and 200 control subjects (CS) from Southern Mexico. Genotyping was performed by conventional PCR and PCR‐RFLP methods. <italic>MIF</italic> mRNA expression was quantified by real‐time PCR and MIF serum levels were determined by an ELISA kit.</p></sec><sec id="mgg31037-sec-0003"><title>Results</title><p>The 7,7 (−794CATT<sub>5‐8</sub>) and −173CC (−173G > C) genotypes were associated with higher disease activity in RA patients. MIF serum levels were increased, and <italic>MIF</italic> mRNA expression was reduced in RA patients as compared to CS. In addition, RA patients with moderate disease activity had higher MIF levels than those with low disease activity. The −794CATT<sub>5‐8</sub> and −173G > C <italic>MIF</italic> polymorphisms were not associated with RA susceptibility.</p></sec><sec id="mgg31037-sec-0004"><title>Conclusion</title><p>These results suggest an important role of <italic>MIF</italic> polymorphisms and MIF serum levels with disease activity in RA.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><affiliations><list></list><tree><noCountry><name sortKey="Ba Os Ernandez, Christian Johana" sort="Ba Os Ernandez, Christian Johana" uniqKey="Ba Os Ernandez C" first="Christian Johana" last="Ba Os-Hernández">Christian Johana Ba Os-Hernández</name><name sortKey="Bucala, Richard" sort="Bucala, Richard" uniqKey="Bucala R" first="Richard" last="Bucala">Richard Bucala</name><name sortKey="Hernandez Ello, Jorge" sort="Hernandez Ello, Jorge" uniqKey="Hernandez Ello J" first="Jorge" last="Hernández-Bello">Jorge Hernández-Bello</name><name sortKey="Illades Guiar, Berenice" sort="Illades Guiar, Berenice" uniqKey="Illades Guiar B" first="Berenice" last="Illades-Aguiar">Berenice Illades-Aguiar</name><name sortKey="L Pez Uintero, Andres" sort="L Pez Uintero, Andres" uniqKey="L Pez Uintero A" first="Andres" last="L Pez-Quintero">Andres L Pez-Quintero</name><name sortKey="Mu Oz Alle, Jose Francisco" sort="Mu Oz Alle, Jose Francisco" uniqKey="Mu Oz Alle J" first="José Francisco" last="Mu Oz-Valle">José Francisco Mu Oz-Valle</name><name sortKey="Navarro Arza, Jose Eduardo" sort="Navarro Arza, Jose Eduardo" uniqKey="Navarro Arza J" first="José Eduardo" last="Navarro-Zarza">José Eduardo Navarro-Zarza</name><name sortKey="Parra Ojas, Isela" sort="Parra Ojas, Isela" uniqKey="Parra Ojas I" first="Isela" last="Parra-Rojas">Isela Parra-Rojas</name><name sortKey="Santoscoy Scencio, Guillermo" sort="Santoscoy Scencio, Guillermo" uniqKey="Santoscoy Scencio G" first="Guillermo" last="Santoscoy-Ascencio">Guillermo Santoscoy-Ascencio</name><name sortKey="Valdes Lvarado, Emmanuel" sort="Valdes Lvarado, Emmanuel" uniqKey="Valdes Lvarado E" first="Emmanuel" last="Valdés-Alvarado">Emmanuel Valdés-Alvarado</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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